Internalizing and externalizing behaviors in high school adolescents in a northern border city of Mexico and their type of family / Conductas internalizantes y externalizantes en adolescentes de una escuela preparatoria en una ciudad fronteriza al norte de México y su tipo de familia

Objective: Identify externalizing and internalizing behaviors in high school adolescents in three schools in a northern border city in Mexico and their type of family. Design: Cross-sectional survey. Location: Three schools in the city of Tijuana, Mexico: two public and one private. Participants: 454 baccalaureate students 14–19 years old. Main measurements: We utilized Youth Self Report Scale, adapted and validated in Spanish, that measure internalization behaviors (anxiety, depression, isolation or somatic complaints), and externalization behaviors (verbal aggressiveness, delinquent behavior and attention-seeking). For dichotomous discrimination between deviant and nondeviant scores, we use the borderline clinical range by classifying YSR scale's T scores≥60, and to analyze the relationship between behavior problems or competencies and living or not in a nuclear family we utilized multiple logistic regression. Results: 55% were female, mean age 16.4 years±0.98, and 62.3% came from a nuclear family. Prevalence of internalizing behaviors was 15.6%, and externalizing behaviors 14.8%. Women had statistically higher mean scores in depressive, anxious and verbally aggressive behavior, somatic complaints, and thought problems. The prevalence of internalizing behaviors in adolescents with nuclear family was 11.7% (n=33), and for adolescents with another type of family was 22.2% (n=38), OR 2.17 (CI 95% 1.30–3.61, p=0.003), but no differences was observed for externalizing behaviors and family type. When adjusted for sex, age, and public or private school, internalizing behaviors and specifically depressive behavior remained significant. Conclusions: We detected a moderate prevalence of internalizing behaviors in Mexican adolescents, predominantly among women, and also observed that not living with a nuclear family increases the odds of presenting internalizing behaviors...(AU)

Objetivo: Identificar conductas internalizantes y externalizantes en adolescentes de escuelas preparatorias en una ciudad fronteriza al norte de México y su tipo de familia. Diseño: Encuesta transversal. Emplazamiento: Tres escuelas de la ciudad de Tijuana, México: dos públicas y una privada. Participantes: 454 estudiantes de preparatoria de 14-19 años de edad. Principales mediciones: Se utilizó la escala Youth Self Report validada al español, que mide conductas internalizantes (ansiedad, depresión, aislamiento y quejas somáticas) y externalizantes (agresión verbal, conducta delictiva y búsqueda de atención). Para la discriminación dicotómica entre puntajes desviados y no desviados, usamos el rango clínico límite al clasificar los T scores de ≥ 60 de la escala YSR, y para analizar la relación entre problemas de comportamiento o competencias y vivir o no en una familia nuclear utilizamos regresión logística múltiple. Resultados: El 55% eran mujeres, la media de edad fue de 16.4 años±0.98, y el 62.3% procedían de familias nucleares. La prevalencia de conductas internalizantes fue de 15.6% y de conductas externalizantes de 14.8%. Las mujeres tenían puntuaciones medias estadísticamente más altas en conducta depresiva, ansiosa y verbalmente agresiva, quejas somáticas y problemas de pensamiento. La prevalencia de conductas internalizantes en adolescentes con familia nuclear fue de 11.7% (n=33), y para adolescentes con otro tipo de familia fue de 22.2% (n=38), OR 2.17 (IC 95% 1.30-3.61, p=0.003), pero no se observaron diferencias para conductas externalizantes y tipo de familia. Al ajustar por sexo, edad y escuela pública o privada, las conductas internalizantes y específicamente la conducta depresiva se mantuvieron significativas...(AU)

Internalizing and externalizing behaviors in high school adolescents in a northern border city of Mexico and their type of family.

OBJECTIVE: Identify externalizing and internalizing behaviors in high school adolescents in three schools in a northern border city in Mexico and their type of family. DESIGN: Cross-sectional survey. LOCATION: Three schools in the city of Tijuana, Mexico: two public and one private. PARTICIPANTS: 454 baccalaureate students 14-19 years old. MAIN MEASUREMENTS: We utilized Youth Self Report Scale, adapted and validated in Spanish, that measure internalization behaviors (anxiety, depression, isolation or somatic complaints), and externalization behaviors (verbal aggressiveness, delinquent behavior and attention-seeking). For dichotomous discrimination between deviant and nondeviant scores, we use the borderline clinical range by classifying YSR scale's T scores≥60, and to analyze the relationship between behavior problems or competencies and living or not in a nuclear family we utilized multiple logistic regression. RESULTS: 55% were female, mean age 16.4 years±0.98, and 62.3% came from a nuclear family. Prevalence of internalizing behaviors was 15.6%, and externalizing behaviors 14.8%. Women had statistically higher mean scores in depressive, anxious and verbally aggressive behavior, somatic complaints, and thought problems. The prevalence of internalizing behaviors in adolescents with nuclear family was 11.7% (n=33), and for adolescents with another type of family was 22.2% (n=38), OR 2.17 (CI 95% 1.30-3.61, p=0.003), but no differences was observed for externalizing behaviors and family type. When adjusted for sex, age, and public or private school, internalizing behaviors and specifically depressive behavior remained significant. CONCLUSIONS: We detected a moderate prevalence of internalizing behaviors in Mexican adolescents, predominantly among women, and also observed that not living with a nuclear family increases the odds of presenting internalizing behaviors. It is important that parents, teachers, and healthcare workers remain vigilant to detect these problems in a timely manner and develop interventions to improve the mental health and well-being of adolescents.

Diagnóstico de la variante conductual de demencia frontotemporal basado en estadios clínicos adaptado para países con baja educación: el caso de Perú

Demencia frontotemporal (DFT) es una condición neurodegenerativa escasamente reconocida en personas menores a 65 años de edad. El diagnóstico de DFT variante conductual (DFTvc) se basa en una entrevista clínica comprehensiva, complementada por una evaluación multidimensional (neurológica, cognitiva, neuropsiquiátrica, de biomarcadores e imágenes cerebrales) adaptada y validada a la población a estudiar; sin embargo, a pesar del incremento de su prevalencia en Latinoamérica y el Caribe, existe necesidad de herramientas estandarizadas y un consenso para el diagnóstico de DFTvc. El artículo intenta realizar una aproximación del enfoque de diagnóstico de DFTvc en escenario de paises con bajos y medianos ingresos, como el Perú.

Frontotemporal dementia (FTD) is a widely recognized neurodegenerative condition in people under 65 years old. The diagnosis of behavioral variant FTD (bvFTD) is based on a comprehensive clinical assessment, complemented by a multidimensional assessment (neurological, cognitive, neuropsychiatric, biomarker and brain imaging) adapted and validated to the population to be studied; however, despite its increasing prevalence in Latin America and the Caribbean, there is a need for standardized tools and consensus for the bvFTD diagnosis. The manuscript attempts to approximate the approach for the diagnosis of bvFTD in the setting of low and middle-income countries, including Peru.

Evaluación de síntomas neuropsiquiátricos para la detección temprana de trastorno neurocognoscitivo / Evaluation of neuropsychiatry symptoms for the early detection of neurocognitive disorder

RESUMEN INTRODUCCIÓN: El diagnóstico oportuno del trastorno neurocognitivo es de los principales retos en la atención de los trastornos neurocognitivos. Por esto, se han generado estrategias para la detección preclínica de la enfermedad, entre ellas las destinadas a evaluar síntomas neuropsiquiátricos (NPS) como la escala Mild Behavior Impairment - Checklist (MBI-C). MÉTODOS: Inicialmente se realizó una búsqueda en BVSalud, Medline y PsycNet, luego se realizó una búsqueda en bola de nieve. Se incluyeron términos referentes a deterioro comportamental leve (abarcando los NPS en etapas tempranas), deterioro cognitivo leve y términos específicos del MBI-C. RESULTADOS: La presencia de NPS se asocia con un aumento en la incidencia anual de demencia. Al evaluarlos con MBI-C, su puntuación se correlaciona con biomarcadores como una mayor atrofia cortical, la presencia de la proteína β-amiloide, así como disminución en funciones ejecutivas como la capacidad de enfocar la atención y la memoria de trabajo. DISCUSIÓN: Los hallazgos en la literatura sugieren la utilidad de MBI-C como marcador de neurodegeneración en estadios previos a la demencia, esto mediante la evaluación de su capacidad predictiva de forma independiente y al compararla con otros biomarcadores. CONCLUSIONES: MBI-C supone ser un instrumento de fácil aplicabilidad e interpretación, sostenible e incluyente. Sin embargo, quedan vacíos sobre la pertinencia de esta escala, por lo que surge la necesidad de investigar este tema.

ABSTRACT INTRODUCTION: Early diagnosis of neurocognitive disorder is the main challenge of dementia health attention. Therefore, strategies for preclinical detection of the disease have been created, like those intended to evaluate neuropsychiatric symptoms (NPS), like the Mild Behavior Impairment - Checklist (MBI-C). METHODS: Research was performed in BVSalud, Medline, and Psynet. Then a snowball sampling was done. The terms included were mild behavioral impairment (included NPS in initial stages), mild cognitive impairment, and specific terms of MBI-C. RESULTS: The presence of NPS increase the incidence of dementia, with an annual conversion rate of 9%. About MBI-C, the score has been related to biomarkers like worse brain atrophy in patients with Parkinson's Disease and a positive relationship with the presence of B-amyloid protein. Also, Creese and cols. show that mild behavioral impairment (measured by MBI-C) is associated with a faster decrease in attention and working memory. DISCUSSION: MBI-C utility as a neurodegenerative marker has been demonstrated to detect cognitive, neuropsychiatry, and functional symptoms that may precede dementia by evaluating its predictive capacity alone and comparing it to other biomarkers. CONCLUSION: MBI-C is easy to apply and interpret, is sustainable and inclusive. However, there are still gaps in the relevance of the scale, so there is the need to continue investigating this topic.

Síntomas conductuales y emocionales de adolescentes que consultan a un programa especializado de trastornos de la conducta alimentaria / Behavioural and Emotional Symptoms of Adolescents Consulting a Specialised Eating Disorders Programme

RESUMEN Introducción: Los trastornos de la conducta alimentaria (TCA) son afecciones complejas de origen multifactorial que tienen como principal característica la preocupación excesiva por el peso y la forma del cuerpo, que causa gran malestar y afectación física llevando a una disminución de la calidad de vida y alteraciones de la funcionalidad del paciente y su entorno social. El objetivo de este estudio es describir los síntomas de orden emocional y conductual de los adolescentes que consultan en la ciudad de Bogotá a un programa especializado en TCA. Métodos: Estudio observacional y descriptivo de corte transversal, para el que se reclutó a pacientes de 11-19 arios con diagnóstico de TCA. Resultados: Se incluyeron 40 pacientes con diagnóstico de TCA, el 92% mujeres. El promedio de edad de los pacientes fue 16,6 ± 1,9 años. El 57% de los pacientes viven en hogar biparental y el 30%, en hogar monoparental. El 72% de la población tenía un rendimiento académico excelente. El 50% de los pacientes estaban moderadamente enfermos. El 60% estaba en tratamiento farmacológico con ISRS. El 65% de los pacientes cumplían criterios clínicos de trastorno de ansiedad; el 30%, de trastorno depresivo; el 22,5%, de problemas de agresividad, y el 17,5%, de conducta delictiva. El 72,5% de la muestra muestra criterios clínicos de síntomas internalizantes y el 42,5%, de síntomas externalizantes, y la mayoría de ellos son pacientes con diagnóstico de bulimia nerviosa. Conclusiones: Los pacientes con bulimia nerviosa obtuvieron en los diferentes síntomas de orden emocional y conductual puntuaciones superiores que con los demás trastornos alimentarios. Esta entidad ofrece mayor psicopatología, la cual se debe examinar rigurosamente al momento de la atención clínica, buscando disminuir el impacto funcional que estos síntomas generan en el individuo.

ABSTRACT Introduction: Eating disorders (EDs) are complex conditions of multifactorial origin. Their main characteristic is excessive concern about body weight and shape, which causes great discomfort and physical problems and leads to a decrease in quality of life and alterations in the patient's functionality social environment. The objective of this study is to describe the emotional and behavioural symptoms of adolescents who consult a specialised ED programme in the city of Bogota. Methods: Observational, descriptive, cross-sectional study, for which patients between 11 and 19 years old with an ED diagnosis were recruited. Results: Forty patients with an ED diagnosis were included, of which 92% were female. The mean age of the patients was 16.6 ± 1.9 years; 57% of patients live in a two-parent home and 30% in a single-parent home; 72% of the sample had excellent academic performance; 50% were moderately ill; 60% received pharmacological management with SSRIs; 65% of patients met clinical criteria for anxiety disorder, 30% for depressive disorder; 22.5% had aggression problems; 17.5% criminal behaviour; 72.5% of the sample met clinical criteria for internalising symptoms and 42.5% for externalising symptoms, the majority being patients with a diagnosis of bulimia nervosa. Conclusions: Patients with bulimia nervosa obtained higher scores in the different emotional and behavioural symptoms than those with other eating disorders. This condition is associated with greater psychopathology, which must be examined rigorously at the time of clinical care, seeking to reduce the functional impact that these symptoms generate on the individual.

Behavioural and emotional symptoms of adolescents consulting a specialised eating disorders programme.

INTRODUCTION: Eating disorders (EDs) are complex conditions of multifactorial origin. Their main characteristic is excessive concern about body weight and shape, which causes great discomfort and physical problems and leads to a decrease in quality of life and alterations in the patient's functionality social environment. The objective of this study is to describe the emotional and behavioural symptoms of adolescents who consult a specialised ED programme in the city of Bogota. METHODS: Observational, descriptive, cross-sectional study, for which patients between 11 and 19 years old with an ED diagnosis were recruited. RESULTS: Forty patients with an ED diagnosis were included, of which 92% were female. The mean age of the patients was 16.6±1.9 years; 57% of patients live in a two-parent home and 30% in a single-parent home; 72% of the sample had excellent academic performance; 50% were moderately ill; 60% received pharmacological management with SSRIs; 65% of patients met clinical criteria for anxiety disorder, 30% for depressive disorder; 22.5% had aggression problems; 17.5% criminal behaviour; 72.5% of the sample met clinical criteria for internalising symptoms and 42.5% for externalising symptoms, the majority being patients with a diagnosis of bulimia nervosa. CONCLUSIONS: Patients with bulimia nervosa obtained higher scores in the different emotional and behavioural symptoms than those with other eating disorders. This condition is associated with greater psychopathology, which must be examined rigorously at the time of clinical care, seeking to reduce the functional impact that these symptoms generate on the individual.

Behavioural and Emotional Symptoms of Adolescents Consulting a Specialised Eating Disorders Programme. / Síntomas conductuales y emocionales de adolescentes que consultan a un programa especializado de trastornos de la conducta alimentaria.

INTRODUCTION: Eating disorders (EDs) are complex conditions of multifactorial origin. Their main characteristic is excessive concern about body weight and shape, which causes great discomfort and physical problems and leads to a decrease in quality of life and alterations in the patient's functionality social environment. The objective of this study is to describe the emotional and behavioural symptoms of adolescents who consult a specialised ED programme in the city of Bogota. METHODS: Observational, descriptive, cross-sectional study, for which patients between 11 and 19 years old with an ED diagnosis were recruited. RESULTS: Forty patients with an ED diagnosis were included, of which 92% were female. The mean age of the patients was 16.6±1.9 years; 57% of patients live in a two-parent home and 30% in a single-parent home; 72% of the sample had excellent academic performance; 50% were moderately ill; 60% received pharmacological management with SSRIs; 65% of patients met clinical criteria for anxiety disorder, 30% for depressive disorder; 22.5% had aggression problems; 17.5% criminal behaviour; 72.5% of the sample met clinical criteria for internalising symptoms and 42.5% for externalising symptoms, the majority being patients with a diagnosis of bulimia nervosa. CONCLUSIONS: Patients with bulimia nervosa obtained higher scores in the different emotional and behavioural symptoms than those with other eating disorders. This condition is associated with greater psychopathology, which must be examined rigorously at the time of clinical care, seeking to reduce the functional impact that these symptoms generate on the individual.

Behavioural Disturbances in Patients with Diagnosis of Neurocognitive Disorder in Bogotá (Colombia). / Alteraciones del comportamiento de pacientes con diagnóstico de trastorno neurocognoscitivo en Bogotá (Colombia).

INTRODUCTION: The main aim of this study is to determine the prevalence of behavioural disturbances (BD) in a group of patients with diagnosis of neurocognitive disorders assessed by a memory clinic in a referral assessment centre in Bogotá, Colombia, in 2015. MATERIAL AND METHODS: This is an observational, retrospective descriptive study of 507 patients with a diagnosis of neurocognitive disorder (according to DSM-5 criteria) evaluated in a referral centre in Bogotá, Colombia, in 2015. RESULTS: Among the group of patients assessed, analyses reveal mean age for minor neurocognitive disorders of 71.04 years, and 75.32 years for major neurocognitive disorder (P <0.001). A total of 62.72% of the sample were female. The most prevalent aetiology of the neurocognitive disorders was Alzheimer's disease, followed by behavioural variant frontotemporal dementia and neurocognitive disorders due to multiple aetiologies. BD occur more frequently in neurocognitive disorder due to behavioural variant frontotemporal dementia (100%), Alzheimer's disease (77.29%) and vascular disease (76.19%). The most prevalent BD in the group assessed were apathy (50.75%), irritability (48.45%), aggression (16.6%), and emotional lability (14.76%). CONCLUSIONS: BD are highly prevalent in patients with diagnosis of major neurocognitive disorder. BD are more prevalent in behavioural variant frontotemporal dementia than any other group. Apathy, irritability, emotional lability and aggression are the BD that occur with greater prevalence in our sample. We discuss the importance of BD in the clinical progression of neurocognitive disorders.

Alteraciones del comportamiento de pacientes con diagnóstico de trastorno neurocognoscitivo en Bogotá (Colombia) / Behavioural Disturbances in Patients with Diagnosis of Neurocognitive Disorder in Bogotá (Colombia)

RESUMEN Introducción: El objetivo de este estudio es determinar la frecuencia de alteraciones conductuales (AC) en un grupo de pacientes con diagnóstico de trastorno neurocognoscitivo (TN) valorado por clínica de memoria en un centro de evaluación en Bogotá, Colombia, durante el ano 2015. Material y métodos: Estudio observacional descriptivo y de corte retrospectivo de 507 pacientes con diagnóstico de trastorno neurocognoscitivo (según criterios del DSM-5), valorados en un centro de referencia en Bogotá en 2015. Resultados: La media de edad de los sujetos con trastorno neurocognoscitivo leve en el momento del diagnóstico era 71,04 arios y la de aquellos con trastorno neurocognoscitivo mayor, 75,32 años (p < 0,001). El 62,72% de la muestra son mujeres. La etiología más frecuente del trastorno neurocognoscitivo fue la enfermedad de Alzheimer probable, seguida por la degeneración lobar frontotemporal, variante conductual, y el trastorno neurocognoscitivo debido a múltiples etiologías. Las AC se presentan con mayor frecuencia en TN debido a degeneración frontotemporal variante conductual (100%), enfermedad de Alzheimer (77,29%) y vascular (76,19%). Las AC más prevalentes en el grupo evaluado fueron la apatía (50,75%), la irritabilidad (48,45%), la agresividad (16,6%) y la labilidad emocional (14,76%). Conclusiones: Las AC son prevalentes en pacientes con diagnóstico de trastorno neurocognoscitivo mayor. Según la etiología del trastorno neurocognoscitivo mayor, las AC son más prevalentes en la degeneración frontotemporal variante conductual. Apatía, irritabilidad, labilidad emocional y agresividad son las AC más comunes en toda la muestra.

ABSTRACT Introduction: The main aim of this study is to determine the prevalence of behavioural disturbances (BD) in a group of patients with diagnosis of neurocognitive disorders assessed by a memory clinic in a referral assessment centre in Bogotá, Colombia, in 2015. Material and methods: This is an observational, retrospective descriptive study of 507 patients with a diagnosis of neurocognitive disorder (according to DSM-5 criteria) evaluated in a referral centre in Bogotá, Colombia, in 2015. Results: Among the group of patients assessed, analyses reveal mean age for minor neurocognitive disorders of 71.04 years, and 75.32 years for major neurocognitive disorder (P < 0.001). A total of 62.72% of the sample were female. The most prevalent aetiology of the neurocognitive disorders was Alzheimer's disease, followed by behavioural variant fronto-temporal dementia and neurocognitive disorders due to multiple aetiologies. BD occur more frequently in neurocognitive disorder due to behavioural variant frontotemporal dementia (100%), Alzheimer's disease (77.29%) and vascular disease (76.19%). The most prevalent BD in the group assessed were apathy (50.75%), irritability (48.45%), aggression (16.6%), and emotional lability (14.76%). Conclusions: BD are highly prevalent in patients with diagnosis of major neurocognitive disorder. BD are more prevalent in behavioural variant frontotemporal dementia than any other group. Apathy, irritability, emotional lability and aggression are the BD that occur with greater prevalence in our sample. We discuss the importance of BD in the clinical progression of neurocognitive disorders.

Trastornos neuroconductuales en la demencia tipo Alzheimer / Neurobehavioral disorders in Alzheimers dementia type

Resumen Los trastornos neuroconductuales (TNC) son síntomas de la percepción alterada, del contenido del pensamiento, estado de ánimo o del comportamiento, aunque se desconocen qué tipos de TNC específicos están afectados en la Demencia tipo Alzheimer (DTA). El objetivo del estudio fue investigar los TNC en pacientes con DTA en comparación con sujetos sin deterioro cognitivo (SSDC). Se estudiaron 50 pacientes con DTA y 60 SSDC en un estudio no experimental-transversal con un muestreo no probabilístico en base a una serie de criterios de inclusión. Tras la aplicación del inventario neuropsiquiátrico, los resultados demostraron que los pacientes con DTA tienen mayor afectación de TNC como la ansiedad, depresión, apatía, irritabilidad, agitación en comparación con SSDC. Los SSDC presentan alteraciones en los TNC de depresión, ansiedad, apatía y alteraciones del sueño. En conclusión, los resultados confirman la hipótesis de que en la DTA se produce una mayor afectación de los TNC en comparación que los SSDC.

Abstract Neurobehavioral disorders (NBD) are symptoms of altered perception, content of thought, mood or behavior, although what specific types of NBD are affected in Alzheimer-type dementia (ATD) are unknown. The aim of the study is to investigate NBD in patients with ATD compared to Subjects without cognitive impairment (SWCI). Fifty patients with ATD and 60 SWCI were studied in a non-experimental-cross-sectional study with a non-probability sampling based on a series of inclusion criteria. After applying the neuropsychiatric inventory, the results showed that patients with ATD have greater involvement of NBD such as anxiety, depression, apathy, irritability, agitation compared to SWCI. The SWCI present alterations in the NBD of depression, anxiety, apathy and sleep disorders. In conclusion, the results confirm the hypothesis that a greater affectation of NBD occurs in ATD compared to SWCI.

Las diferentes facetas de la encefalitis autoinmune / The different facets of autoinmune encephalitis

RESUMEN INTRODUCCIÓN: La encefalitis autoinmune es causada por mecanismos inmunes antineuronales, su presentación clínica es heterogénea, los criterios clínicos y paraclínicos disponibles orientan el abordaje, sin embargo, el reto ocurre cuando no hay autoanticuerpos detectables en suero o líquido cefalorraquídeo (LCR). METODOLOGÍA: Reportamos cuatro casos destacando la variabilidad de las manifestaciones clínicas, que ante la ausencia de anticuerpos (negativos finalmente en tres de los casos) fueron tratados con inmunoterapia con buena respuesta. CONCLUSIÓN: En sitios donde no se dispone de medición de anticuerpos de manera expedita, o a pesar de ser estos negativos, ante la sospecha clínica, apoyado de estudios de LCR, resonancia magnética nuclear y registro electroencefalográfico, se sugiere iniciar inmunoterapia temprana, usualmente dando lugar a reversibilidad del trastorno neurológico.

SUMMARY INTRODUCTION: Autoimmune encephalitis is caused by antineuronal immune mechanisms, its clinical presentation is heterogeneous, clinical and paraclinical criteria guide the approach, however, the challenge occurs when there are no detectable autoantibodies in serum or cerebrospinal fluid. METHODOLOGY: We report four cases that highlight the variability of clinical manifestations, which in the absence of antibodies (finally negative in three of the cases) were treated with immunotherapy with good response. CONCLUSION: In places where antibody measurement is not available expeditiously, or despite it being negative, given clinical suspicion, supported by CSF studies, magnetic resonance imaging and electroencephalographic recording, it is suggested to start early immunotherapy, usually resulting in the reversibility of the neurological disorder.

El síntoma / The symptom

El síntoma entendido por alteraciones subjetivas percibidas por las per-sonas ha sido desarrollado desde los años 50 por los psiquiatras y en los años 70 por psicólogos clínicos. Una sinopsis completa de esta alteración se resume en el libro de Süllwold y Huber, desde 1974. Los síntomas son alteraciones subclínicas sutiles y subjetivamente experimentadas en el im-pulso, el afecto, el pensamiento, el habla, la percepción (corporal), la acción motora, las funciones vegetativas centrales y la tolerancia al estrés. Por definición, los síntomas son diferentes de lo que se considera el ser mental "normal" de uno. Al ser subjetivos, siguen siendo predominantemente pri-vados y aparentes solo para la persona afectada, y raramente son obser-vables. Los síntomas básicos difieren de los síntomas negativos tal como se los entiende actualmente, es decir, como déficit funcionales observables por otros. La percepción de que algo está mal con el pensamiento de uno está presente; sin embargo, algunas experiencias pueden ser tan nuevas y extrañas que siguen siendo casi inexplicables. En el campo de la medicina, las enfermeras ayudan a los pacientes a hacer frente a la angustia de los síntomas, mientras que los médicos se preocupan principalmente por la aparición de síntomas en el diagnóstico o tratamiento de la enfermedad.(AU)

The symptom understood by subjective alterations perceived by people has been developed since the 50s by psychiatrists and in the 70s by clinical psychologists. A complete synopsis of this alteration is summarized in the book written by Süllwold and Huber, since 1974. The symptoms are subtle and subjectively subclinical experienced alterations in impulse, affection, thought, speech, (body) perception, motor action, central vegetative functions and stress tolerance. By definition, the symptoms are different from what is considered to be the "normal" mental being of one. Being subjective, they remain predominantly private and apparent only for the affected person, and they are rarely observable. The basic symptoms differ from the negative symptoms as they are currently understood, that is, as functional deficits observable by others. The perception that something is wrong with one's thinking is present; however, some experiences may be so new and strange that they remain almost inexplicable. In the medical field, nurses help patients to cope to the symptoms, while doctors are primarily concerned with the appearance of symptoms in the diagnosis or treatment of the disease.(AU)

Care complexity in hospitalized elderly according to cognitive performance / Complejidad asistencial en ancianos hospitalizados según desempeño cognitivo / Complexidade assistencial em idosos hospitalizados conforme desempenho cognitivo

ABSTRACT Objective: to investigate possible differences in care complexity, functional performance and biopsychosocial and health system aspects among hospitalized elderly with or without cognitive decline. Method: quantitative, cross-sectional and analytical study in which was used the INTERMED method and cognitive and functional screening scales. We investigated 384 elderly patients admitted to a medical and surgical clinic of a University Hospital located in São Paulo/SP. Results: cognitive decline was present in 40.1% of the sample, most of them were longer-lived elderly individuals with less schooling and income, more dependent in activities of daily living and had greater vulnerability in different domains of INTERMED. After adjustments, the elderly with cognitive decline presented greater vulnerability in the psychological domain. Conclusion: the relationship between cognitive decline and psychological vulnerability highlights the need to adopt long-term care based on involvement of the family, health team and different services, thereby maximizing the quality of care.

RESUMEN Objetivo: investigar posibles diferencias en la complejidad asistencial, desempeño funcional, y en los aspectos biopsicosociales y del sistema de salud entre ancianos hospitalizados con o sin declinación cognitiva. Método: estudio cuantitativo, transversal y analítico que utilizó el método INTERMED y escalas de rastreo cognitivo y funcional. Se investigaron 384 ancianos internados en clínica médica y quirúrgica de un Hospital Universitario ubicado en São Paulo/SP. Resultados: se obtuvo que el 40,1% de la muestra presentó declinación cognitiva, la mayoría compuesta por ancianos más longevos, del sexo femenino, con menor escolaridad e ingresos, más dependientes para las actividades de vida diaria y con mayor vulnerabilidad en diferentes dominios del INTERMED. Después de ajustes, los ancianos con declinación cognitiva presentaron mayor vulnerabilidad en el dominio psicológico. Conclusión: la relación entre declinación cognitiva y vulnerabilidad psicológica destaca la necesidad de adoptar cuidados de larga duración basados en la participación de la familia, del equipo de salud y de los diferentes servicios, maximizando la calidad de la atención.

RESUMO Objetivo: investigar possíveis diferenças na complexidade assistencial, desempenho funcional e aspectos biopsicossociais e de sistema de saúde entre idosos hospitalizados com ou sem declínio cognitivo. Método: estudo quantitativo, transversal e analítico que utilizou o método INTERMED e escalas de rastreio cognitivo e funcional. Foram investigados 384 idosos internados em clínica médica e cirúrgica de um Hospital Universitário em São Paulo/SP. Resultados: Houve declínio cognitivo em 40,1% da amostra, cuja maior parte era de idosos mais longevos e do sexo feminino, com menor escolaridade e renda, mais dependentes para as atividades de vida diária e com maior vulnerabilidade em diferentes domínios do INTERMED. Após ajustes, os idosos com declínio cognitivo apresentaram maior vulnerabilidade no domínio psicológico. Conclusão: A relação entre declínio cognitivo e vulnerabilidade psicológica destaca a necessidade de adotar cuidados de longa duração pautados no envolvimento da família, da equipe de saúde e dos diferentes serviços para qualidade da assistência.

Indicadores Psicológicos e Comportamentais na Perícia do Abuso Sexual Infantil / Indicadores Psicológicos y Conductuales en la Pericia del Abuso Sexual Infantil / Psychological and Behavioral Indicators in the Forensic Assessment of Child Sexual Abuse

Resumo Este estudo avaliou a capacidade discriminante de indicadores psicológicos e comportamentais frequentemente associados ao abuso sexual infantil. A amostra foi constituída por 79 crianças, de ambos os sexos, sendo 63,3% do sexo feminino (n = 50), com idades entre oito e 12 anos (M = 9,92; DP = 1,45). Os participantes foram distribuídos em três grupos: Abuso sexual (n = 34), Maus-tratos sem histórico de abuso sexual (n = 14) e Sintomas clínicos sem histórico de maus-tratos (n = 31). Foram administrados instrumentos com os responsáveis e com as crianças. Para identificar os fatores que diferenciavam os grupos, foi realizada a Análise de regressão logística multinominal. A variável Preocupações sexuais foi significativa para diferenciar o grupo Abuso sexual dos outros dois grupos. O modelo apresentou capacidade preditiva geral de classificar corretamente 69,6% dos casos. Sugere-se que a investigação dessa variável seja incluída, entre outros indicadores, nos procedimentos periciais de crianças com suspeita de abuso sexual. Com base nos resultados obtidos, fica evidente que é necessário cautela no estabelecimento de associações causais entre manifestações comportamentais ou psicológicas e a hipótese de abuso sexual em crianças.

Resumen Este estudio evaluó la capacidad discriminante de indicadores psicológicos y conductuales frecuentemente asociados al abuso sexual infantil. La muestra fue constituida por 79 niños, de ambos sexos, siendo 63,3% do sexo femenino (n = 50), com edades entre ocho y 12 años (M = 9,92; DE = 1,45). Los participantes fueron distribuidos en tres grupos: Abuso sexual (n = 34), Malos tratos sin antecedentes de abuso sexual (n = 14) y Sintomas clínicos sin antecedentes de maltrato (n = 31). Se han administrados instrumentos con los responsables y los niños. Para identificar los factores que diferenciaban a los grupos, se realizó el Análisis de regresión logística multinominal. La variable Preocupaciones sexuales apareció como significativa para diferenciar el grupo Abuso sexual de los otros dos grupos. El modelo presentó la capacidad preditiva general de clasificar correctamente 69,6% de los casos. Se sugerie la inclusión de esta variable, entre otros indicadores, en la evaluación del abuso sexual infantil. En base a los resultados obtenidos, es evidente que es necesario cautela en el establecimiento de asociaciones causales entre manifestaciones comportamentales o psicológicas y la hipótesis de abuso sexual infantil.

Abstract This study evaluated the discriminative ability of behavioral and psychological indicators often associated with child sexual abuse. The sample consisted of 79 children of both genders, 63.3% being female (n = 50), aged between 8 and 12 years (M = 9.92, SD = 1.45). Participants were assigned to three groups: Sexual abuse (n = 34), Maltreatment with no history of sexual abuse (n = 14) and Clinical symptoms with no history of abuse or other traumatic events (n = 31). Assessment measures were administered with the legal guardians and with the children. A multinomial logistic regression analysis was conducted aiming to identify factors for differentiation of the groups. The TSCC Sexual concerns variable emerged as significant in differentiating the Sexual abuse group from both the Maltreatment and Clinical symptoms groups. The model showed overall predictive ability to accurately classify 69.6% of the cases. The investigation of this variable should be included, among other indicators, in forensic procedures for children with suspected sexual abuse. Based on the results, it becomes clear that caution is required in establishing causal relationships between behavioral or psychological manifestations and the hypothesis of child sexual abuse.

Síntomas afectivo-conductuales y estrategias de afrontamiento del dolor en pacientes con fibromialgia (FM) / Affective - behavioral symptoms and coping strategies of pain in patients with fibromyalgia (FM)

Resumen Objetivo: La fibromialgia (FM) es un síndrome de dolor crónico generalizado, asociado a alteraciones emocionales y comportamentales. El objetivo de este estudio fue identificar los síntomas afectivo-conductuales y las estrategias cognitivas de afrontamiento en la percepción de dolor de pacientes con FM. Material y métodos: Se realizó un estudio de corte transversal, con análisis de casos y controles, con una muestra de dos grupos de mujeres, en la ciudad de Barranquilla (Colombia): 34 con diagnóstico de FM y 30 controles, a quienes se les realizó evaluación de síntomas psicológicos y de percepción de dolor. Resultados: Los pacientes con FM presentan significativamente mayores síntomas afectivo-conductuales (ansiedad, depresión, insomnio, somatización y disfunción social) que los sujetos controles (p<0.001), así como una tendencia a utilizar la retirada social como estrategia de afrontamiento (p<0.005). De acuerdo con el análisis factorial, la percepción de dolor y los síntomas afectivo-conductuales en pacientes con FM se agruparon en un mismo factor, lo cual demostró interdependencia de las variables. Conclusiones: Los síntomas afectivo-conductuales se asocian a la percepción de dolor y se relacionan con la utilización de estrategias pasivas y centradas en la emoción como mecanismo para afrontar la experiencia de dolor.

Abstract Objective: Fibromyalgia (FM) is a syndrome of chronic widespread pain associated with emotional and behavioral disorders. The purpose of the study was to identify the affective -behavioral symptoms and cognitive coping strategies involved in the perception of pain in patients with FM. Material and methods: A cross-sectional study was performed, with analysis of cases and controls, with a sample of two groups of women, in the city of Barranquilla (Colombia). Affective - behavioral symptoms and cognitive coping strategies were assessed in 34 patients with FM and 30 controls matched by age and educational level. Results: Our findings indicate greater affective and behavioral symptoms in patients with FM (anxiety, depression, insomnia, somatization and social dysfunction) (p<0.001) and a tendency to use social withdrawal as a coping strategy (p<0.005). According to factor analysis, pain perception and affective-behavioral symptoms were grouped in a single factor, demonstrating interdependence between variables. Conclusions: The affective-behavioral symptoms are associated with perception of pain and are relate to the use of passive strategies, and focused on emotion as a mechanism to confront the experience of pain.

Cognition and behavorial morbidity associated with sleep disordered breathing in children / Alteraciones cognitivas y conductuales en los trastornos respiratorios del sueño (TRS) en niños

Sleeep disorder breathing (SDB) in chilhood includes a broad spectrum of disease ranging from primary snoring to more severe forms of obstructive sleep apnea syndrome. They may be associated with alterations different than those seen in adults, e.g., children present a low percentage of daytime sleepiness. Nevertheless, they present great difficulties in their learning, and failure in memory and attention and reports of behavior of aggressiveness. We analyze in the present review the cognitive and behavioral deficits asscoaited with the RDS and the main tests that are made for its study

Los trastornos respíratorios del sueño (TRS) en la infancia incluyen un amplio espectro que comprende desde el ronquido primario hasta las formas más graves de síndrome de apnea obstructiva del sueño (SAOS). Los niños presentan sintomatología asociada distinta a los adultos, como un bajo porcentaje de sonmolencia diurna. No obstante refieren dificultades en su aprendizaje, fallas en memoria, atención y cambios en su hiperactividad y agresividad. Se analizan los déficit cognitivos y conductuales asociados a los TRSy las principales pruebas neuropsicológicas o test que se realizan para su estudio

Behavioural and psychiatric symptoms in cognitive neurology. / Síntomas conductuales y psiquiátricos en neurología cognitiva.

Behavioural and psychiatric symptoms (BPS) are frequent in neurological patients, contribute to disability, and decrease quality of life. We recorded BPS prevalence and type, as well as any associations with specific diagnoses, brain regions, and treatments, in consecutive outpatients examined in a cognitive neurology clinic. METHOD: A retrospective analysis of 843 consecutive patients was performed, including a review of BPS, diagnosis, sensory impairment, lesion topography (neuroimaging), and treatment. The total sample was considered, and the cognitive impairment (CI) group (n=607) was compared to the non-CI group. RESULTS: BPS was present in 59.9% of the patients (61.3% in the CI group, 56.4% in the non-CI group). One BPS was present in 31.1%, two in 17.4%, and three or more in 11.4%. BPS, especially depression and anxiety, are more frequent in women than in men. Psychotic and behavioural symptoms predominate in subjects aged 65 and older, and anxiety in those younger than 65. Psychotic symptoms appear more often in patients with sensory impairment. Psychotic and behavioural symptoms are more prevalent in patients with degenerative dementia; depression and anxiety in those who suffer a psychiatric disease or adverse effects of substances; emotional lability in individuals with a metabolic or hormonal disorder; hypochondria in those with a pain syndrome; and irritability in subjects with chronic hypoxia. Behavioural symptoms are more frequent in patients with anomalies in the frontal or right temporal or parietal lobes, and antipsychotics constitute the first line of treatment. Leaving standard treatments aside, associations were observed between dysthymia and opioid analgesics, betahistine and statins, and between psychotic symptoms and levodopa, piracetam, and vasodilators.

Correlation and agreement between depressive symptoms in children and their parent's perception / Correlación y concordancia entre síntomas depresivos en niños y su percepción por los padres

ABSTRACT: Introduction: Childhood depression is a disease that is becoming more frequent. Few reports address parental perception of children depressive symptoms, and these studies have not been carried out in community samples. Objective: To evaluate the correlation and agreement of depressive symptoms in school-age children, and their parent's perception about emotional and conduct abnormalities. Method: A transversal study was performed in 284 children who filled a Children Depression Inventory. One of their parents filled a Strengths and Difficulty Questionnaire, and correlation between scores and subcomponent scores were assessed. Agreement between presence of depressive symptoms in children and their parent's perception of abnormal emotional and/or conduct reports was also obtained. Results: 47 children were identified with depressive symptoms. We found moderate correlation between scores. We did not find agreement between the presence of depressive symptoms in the children and the report of emotional and conduct abnormalities by parents. Discussion and conclusion: There is a modest correlation between depressive symptom severity and parental perception of abnormal emotions and/or behaviors. We found no evidence of agreement between these domains in our study, which suggests that parents fail to perceive negative emotions or conducts as depressive symptoms in their children. Parental reports should be addressed by healthcare workers, and their emotional significance should be interpreted. An intentional search of depressive symptomatology in children should be a priority.

RESUMEN: Introducción: La prevalencia de la depresión infantil está al alza. Pocos estudios han evaluado la percepción parental de los síntomas depresivos en niños, y los que se han realizado no han sido replicados en la comunidad. Objetivo: Evaluar la correlación y la concordancia entre los síntomas depresivos en niños de edad escolar con la percepción de sus padres sobre problemas emocionales y conductas anormales. Método: Se realizó un estudio transversal en 284 niños que contestaron el Inventario de Depresión Infantil y se compararon los puntajes con el Cuestionario de Fortalezas y Dificultades que llenó uno de los padres. Se evaluó la correlación entre los puntajes totales y por sub-escalas, así como la concordancia entre la presencia de puntajes sugestivos de depresión infantil y la percepción parental de emociones y conductas anormales. Resultados: 47 niños fueron identificados con puntajes indicativos de sintomatología depresiva. Encontramos correlación moderada entre los puntajes de las escalas. No encontramos concordancia entre la presencia de síntomas depresivos y el reporte parental de emociones o conductas anormales. Discusión y conclusión: Existe correlación entre la severidad de los síntomas depresivos y la percepción parental de emociones y conductas anormales. No encontramos concordancia entre ambas mediciones, lo cual sugiere que los padres fallan al identificar las conductas y emociones anormales de sus hijos como los síntomas depresivos. Los reportes de los padres deben ser tomados en cuenta y ser interpretados por el personal de salud. La búsqueda intencionada de síntomas depresivos en niños debe ser parte fundamental del proceso de cuidado de esta población.

Neuropsychiatric symptoms of the elderly with Alzheimer's disease and the family caregivers' distress / Sintomas neuropsiquiátricos do idoso com doença de Alzheimer e o desgaste do cuidador familiar / Síntomas neuropsiquiátricos de adultos mayores con enfermedad de Alzheimer y el desgaste de los cuidadores familiares

ABSTRACT Objective: to analyze the relationship between the distress of the family caregiver and the presence of neuropsychiatric symptoms in elderly patients with Alzheimer's disease or mixed dementia. Method: a descriptive, cross-sectional study conducted in the Geriatric and Dementias Clinic of a general tertiary hospital, with 96 elderly people with Alzheimer's disease or mixed dementia and their family caregivers. Questionnaires to characterize the elderly and caregivers, and the Neuropsychiatric Inventory were used. Descriptive statistics and Pearson correlation test were performed. Results: 68.7% of the elderly were women, average age 80.8 years, 56.2% had Alzheimer's disease and 43.7%, mixed dementia. Among caregivers, 90.6% were women, average age 56, 70.8% took care of parents and 64.6% lived with the elderly. There was a strong (r = 0.82) and significant (p <0.01) correlation between the total score on the Neuropsychiatric Inventory and the total score on the Neuropsychiatric Inventory-Distress and strong (r = 0.80) and significant (p <0 01) correlation between the total score on the Neuropsychiatric Inventory Distress and the number of neuropsychiatric symptoms, i.e., the higher the number, frequency and severity of these symptoms in the elderly, the more intense is the caregiver distress. Conclusion: the presence of neuropsychiatric symptoms in the elderly was related to increased distress in caregivers.

RESUMO Objetivo: analisar a relação entre o desgaste do cuidador familiar e a presença de sintomas neuropsiquiátricos em idosos com doença de Alzheimer ou demência mista. Método: estudo descritivo, transversal, realizado no Ambulatório de Geriatria e Demências de um Hospital Geral Terciário, com 96 idosos com doença de Alzheimer ou demência mista e seus cuidadores familiares. Foram utilizados o questionário para caracterização dos idosos e cuidadores e o Inventário Neuropsiquiátrico. Foram realizadas estatísticas descritivas e o teste de correlação de Pearson. Resultados: 68,7% dos idosos eram mulheres, média de idade 80,8 anos, 56,2% possuíam doença de Alzheimer e 43,7%, demência mista. Dos cuidadores, 90,6% eram mulheres, média de idade 56 anos, 70,8% cuidavam do pai/mãe e 64,6% moravam com o idoso. Houve correlação forte (r=0,82) e significativa (p<0,01) entre o escore total do Inventário Neuropsiquiátrico e o escore total do Inventário Neuropsiquiátrico Desgaste e correlação forte (r=0,80) e significativa (p<0,01) entre o escore total do Inventário Neuropsiquiátrico Desgaste e o número de sintomas neuropsiquiátricos, ou seja, quanto maiores o número, a frequência e a gravidade destes sintomas nos idosos maior é o desgaste do cuidador. Conclusão: a presença dos sintomas neuropsiquiátricos nos idosos apresentou relação com maior desgaste nos cuidadores.

RESUMEN Objetivo: analizar la relación entre el desgaste del cuidador familiar y la presencia de síntomas neuropsiquiátricos en pacientes ancianos con enfermedad de Alzheimer o demencia mixta. Método: estudio descriptivo, transversal, realizado en la clínica de Geriatría y Demencias de un hospital general terciario, con 96 ancianos con enfermedad de Alzheimer o demencia mixta y sus cuidadores familiares. Se utilizaron cuestionarios para caracterizar los ancianos y cuidadores y el Inventario Neuropsiquiátrico. Se realizaron estadísticas descriptivas y prueba de correlación de Pearson. Resultados: el 68,7% de los ancianos eran mujeres, con una edad promedio de 80,8 años, el 56,2% tenían enfermedad de Alzheimer y el 43,7%, demencia mixta. Entre los cuidadores, el 90,6% eran mujeres, con una media de 56 años, el 70,8% se hacía cargo del padre / madre y el 64,6% vivía con los ancianos. Hubo una fuerte (r = 0,82) y significativa (p <0,01) correlación entre la puntuación total en el Inventario Neuropsiquiátrico y la puntuación total en el Inventario Neuropsiquiátrico-Desgaste y fuerte correlación (r = 0,80) y significativa (p <0 01) entre la puntuación total en el Inventario Neuropsiquiátrico-Desgaste y el número de síntomas neuropsiquiátricos, es decir, cuanto mayor sea el número, la frecuencia y la severidad de estos síntomas en los ancianos, mayor es el desgaste del cuidador. Conclusión: la presencia de síntomas neuropsiquiátricos en los ancianos estaban relacionados con un mayor desgaste en los cuidadores.

Cognitive intervention therapy as treatment for behaviour disorders in Alzheimer disease: evidence on efficacy and neurobiological correlations.

INTRODUCTION: The prevalence of behavioural and psychological symptoms (BPS) is very high among patients with Alzheimer disease (AD); more than 90% of AD patients will present such symptoms during the course of the disease. These symptoms result in poorer quality of life for both patients and caregivers and increased healthcare costs. BPS are the main factors involved in increases to the caregiver burden, and they often precipitate the admission of patients to residential care centres. DEVELOPMENT: Current consensus holds that intervention models combining pharmacological and non-pharmacological treatments are the most effective for AD patients. Several studies have shown cholinesterase inhibitors and memantine combined with cognitive intervention therapy (CIT) to be effective for improving patients' cognitive function and functional capacity for undertaking daily life activities. However, the efficacy of CIT as a treatment for BPS has not yet been clearly established, which limits its use for this purpose in clinical practice. The objective of this review is to gather available evidence on the efficacy of cognitive intervention therapy (CIT) on BPS in patients with AD. CONCLUSIONS: The results of this review suggest that CIT may have a beneficial effect on BPS in patients with AD and should therefore be considered a treatment option for patients with AD and BPS.